Analytical and Clinical Validation of Expressed Variants and Fusions From the Whole Transcriptome of Thyroid FNA Samples.

Introduction: The Afirma® Xpression Atlas (XA) detects gene variants and fusions in thyroid nodule FNA samples from a curated panel of 511 genes utilizing whole-transcriptome RNA-sequencing. Its meant use is amongst cytologically indeterminate nodules which can be Afirma GSC suspicious, Bethesda V/VI nodules, or recognized thyroid metastases. Here we report its analytical and scientific validation. Methods: DNA and … Read more

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